Hollister Wound Supplies 101: Endoform dermal template

*The information provided in this blog is not medical advice and is not intended to, and does not, replace the advice provided by your health care professional. Always seek advice from your licensed healthcare professional in regards to your healthcare needs.

Hollister Wound Care recently announced its newest wound care offering, the Endoform dermal template. It has been designed to deliver the strength of a dermal template with the simplicity of a collagen-based dressing. It is derived from an ovine (sheep) source, and is composed of 90% collagen and 10% intact, native extracellular matrix (ECM).

We thought we’d take this time to answer a few basic questions about the new wound care alternative.

What is ECM?
An important element in living tissue is the ECM. It serves multiple functions, which include regulating intercellular communication and providing structural support to help tissue repair.

What benefits does the Endoform dermal template offer?
Endoform dermal template demonstrates broad spectrum matrix metalloproteinases (MMP) reduction, which we’ll discuss in more detail shortly. It is available to healthcare providers across the continuum of care.  It can be used to treat acute and chronic wounds and may be reimbursed under the collagen HCPCS A Codes. Another key advantage that it can offer EB families is its cost-effectiveness because re-applications can be made as little as once per week.

How is the collagen in Endoform dermal template different from collagen/ORC dressings?
Processed collagen//ORC dressings contain a denatured matrix structure. Endoform dermal template retains the structure and function of the native ECM. 

Why is broad-spectrum MMP reduction relevant?
Chronic wounds typically show high levels of certain MMPs. These MMPs can sequentially degrade the native ECM, delaying wound healing. To reduce excess MMP activity, collagen dressings provide a sacrificial substrate. Endoform dermal template demonstrates broad-spectrum MMP activity reduction. Reduced MMP activity may contribute to better wound healing.

If you would like more information about the Endoform dermal template, please contact me at leslie.rader@hollisterwoundcare.com.

Sources: EB Dressing Products, Hollister Wound Care

  • HCPCS Codes A6021, A6022 collagen dressing.
  • Negron L, Lun S, May BC. Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase. Int Wound J. 2012 Nov 1.
  • Endoform Dermal Template Instructions for Use.
  • International consensus. Acellular matrices for the treatment of wounds. An expert working group review. London: Wounds International, 2010.
  • Medicare Local Coverage Determination (LCD) criteria requires the wound to have been present for a predetermined number of weeks and to have failed to respond to documented conservative measures prior to authorizing reimbursement on more advanced wound therapies such as skin substitutes. Number of weeks varies by region.
  • Lun S, Irvine SM, Johnson KD, Fisher NJ, Floden EW, Negron L, et al. A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials 2010 Jun;31(16):4517-4529.
  • Schultz GS, Mast, BA, Molecular Analysis of the Environments of Healing and Chronic Wounds: Cytokines, Proteases, and Growth Factors. Primary Intention. February 1999.
  • Schultz GS, Ladwig G, Wysocki A. Extracellular matrix: review of its roles in acute and chronic wounds. World Wide Wounds. August 2005.